abstract：:Agosterol A (AG-A) is a novel agent that reverses P-glycoprotein (P-gp) and multidrug resistance protein-1 (MRP1)-meditated multidrug resistance (MDR). We have synthesized [125I]11-azidophenyl agosterol A (azidoAG-A), a photoaffinity analog of AG-A, and characterized its binding to P-gp in membrane vesicles prepared f...

journal_title：Oncology research

authors： Mitsuo M,Noguchi T,Nakajima Y,Aoki S,Ren XQ,Sumizawa T,Haraguchi M,Kobayashi M,Baba M,Nagata Y,Akiyama S,Furukawa T

更新日期：2003-01-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is commonly overexpressed in non-small cell lung cancer (NSCLC) and its tyrosine kinase phosphorylation is thought to be an ideal target in the treatment of patients with NSCLC. In the present study, we examined surgically obtained specimens from a series of 36 NSCLC patients fo...

journal_title：Oncology research

authors： Kanematsu T,Yano S,Uehara H,Bando Y,Sone S

更新日期：2003-01-01 00:00:00

abstract：:Human skin fibroblasts were exposed to global system for mobile communication (GSM) cellular phone radiofrequency for 1 h. GSM exposure induced alterations in cell morphology and increased the expression of mitogenic signal transduction genes (e.g., MAP kinase kinase 3, G2/mitotic-specific cyclin G1), cell growth inhi...

journal_title：Oncology research

authors： Pacini S,Ruggiero M,Sardi I,Aterini S,Gulisano F,Gulisano M

更新日期：2002-01-01 00:00:00

abstract：:Accumulation of beta-catenin in cytoplasm and nuclei is frequently observed in a wide variety of tumors arising, for example, in the colon, liver, uterus, or brain. In association with Tcf/LEF transcription factors, beta-catenin regulates expression of genes involved in the Wnt/wingless signaling pathway, but the prec...

journal_title：Oncology research

authors： Miwa N,Furuse M,Tsukita S,Niikawa N,Nakamura Y,Furukawa Y

更新日期：2001-01-01 00:00:00

abstract：:Angiogenesis, the formation of new vessels, is essential for tumor growth and metastasis. Mutations of p53 tumor suppressor gene are frequent and play an important role in colorectal oncogenesis. A role of p53 as an angiogenesis inhibitor has also been proposed. We evaluated angiogenesis and p53 expression in 16 hyper...

journal_title：Oncology research

authors： Kakolyris SA,Kaklamanis LG,Koukourakis MJ,Giatromanolaki A,Rousomoustakaki M,Souglakos JC,Reppa DK,Georgoulias VA,Gatter KC,Harris AL

更新日期：2000-01-01 00:00:00

abstract：:We investigated the susceptibility of three inbred strains of rats to the hepatocarcinogen, N-nitrosomorpholine (NNM), to establish a spontaneous metastatic model of hepatocellular carcinoma (HCC). WS/Shi. SD/gShi, and F344/DuCrj rats were given 0.02% NNM in drinking water for 8 weeks and thereafter left without any t...

journal_title：Oncology research

authors： Murai T,Mori S,Hosono M,Iwakura Y,Takashima A,Oohara T,Makino S,Takeda R,Fukushima S

更新日期：2000-01-01 00:00:00

abstract：:Our recent studies demonstrated that 12-O-tetradecanoylphorbol-13-acetate (TPA) has pharmacological activity for the treatment of acute myelocytic leukemia patients. In the present study, we investigated the potential synergistic effect of all-trans retinoic acid (RA), 1alpha,25-dihydroxyvitamin D3 (VD3), and sodium b...

journal_title：Oncology research

authors： Zheng X,Chang RL,Cui XX,Kelly KA,Shih WJ,Lin Y,Strair R,Suh J,Han ZT,Rabson A,Conney AH

更新日期：2000-01-01 00:00:00

abstract：:Mutational inactivation of the cyclin-dependent kinase inhibitors (CDKIs) (p16INK4A/MTS1) tumor suppressor gene has been found in a variety of human tumor types. To investigate the involvement of CDKI abnormality in mesenchymal chondrosarcoma, alterations of CDKIs were examined in human mesenchymal chondrosarcoma tiss...

journal_title：Oncology research

authors： Bae DK,Park YK,Chi SG,Lee CW,Unni KK

更新日期：2000-01-01 00:00:00

abstract：:We observed a putative immunocytolytic factor secreted in the supernatant of several pancreatic adenocarcinoma cell lines that induces apoptosis in lymphocytes. A marked reduction in the viability of the target splenocytes was evident after coincubation with the supernatants from various pancreatic adenocarcinoma cell...

journal_title：Oncology research

authors： Divino CM,Angel LP,Brower ST,Chen SH

更新日期：1999-01-01 00:00:00

abstract：:We applied a differential display method to screen mRNAs isolated from a newly established cell line that carried a wild-type p53 transgene under control of the lactose operon. To investigate the p53 signaling pathway, we looked for genes whose expression was significantly induced or suppressed by induction of wild-ty...

journal_title：Oncology research

authors： Okamura S,Ng CC,Koyama K,Takei Y,Arakawa H,Monden M,Nakamura Y

更新日期：1999-01-01 00:00:00

abstract：:Recently, there has been significant effort in developing techniques designed to detect disseminated tumor cells in the peripheral blood (PB). These techniques include immunocytochemical staining of cytocentrifuge slides, flow cytometry, and RT-PCR. Several authors reported various results concerning the sensitivity o...

journal_title：Oncology research

authors： Stimpfl M,Schmid BC,Obermair A,Tong D,Schiebel I,Gitsch G,Leodolter S,Zeillinger R

更新日期：1999-01-01 00:00:00

abstract：:Our recent studies have shown that vanadium, a dietary micronutrient, has an inhibitory response against experimentally induced rat liver carcinogenesis. In the present study, the effect of vanadium on hepatic xenobiotic biotransformation in rats exposed to diethylnitrosamine (DENA, 200 mg/kg, IP) was investigated to ...

journal_title：Oncology research

authors： Bishayee A,Roy S,Chatterjee M

更新日期：1999-01-01 00:00:00

abstract：:Numerous studies have observed that workers in ferriferous industries have an elevated risk of respiratory tract neoplasia. Research at the cellular and animal model levels indicates that iron compounds, per se, are carcinogenic. However, some investigators have suggested that inhaled iron compounds are merely carrier...

journal_title：Oncology research

authors： Weinberg ED

更新日期：1999-01-01 00:00:00

abstract：:We previously reported that vasoactive intestinal polypeptide (VIP) significantly inhibited Matrigel invasion and haptotactic migration of murine colon 26-L5 carcinoma in vitro. To extend our study, we investigated the inhibitory mechanisms of VIP on Matrigel invasion of colon 26-L5 carcinoma, and the effect on metast...

journal_title：Oncology research

authors： Ogasawara M,Murata J,Ayukawa K,Saiki I

更新日期：1998-01-01 00:00:00

abstract：:We investigated the regulatory effect of interleukin (IL) 10 on IL-12-inducible killer activity of blood mononuclear cells (MNC) of healthy subjects. IL-10 suppressed non-MHC-restricted killer activity induced by IL-12 in a dose-dependent manner. Cytotoxicity against Daudi cells of blood MNC activated with optimal dos...

journal_title：Oncology research

authors： Pai K,Yanagawa H,Takauchi E,Suzuki Y,Hanibuchi M,Parajuli P,Sone S

更新日期：1998-01-01 00:00:00

abstract：:Human telomerase is a ribonucleoprotein that maintains telomeres by adding TTAGGG tandem repeat sequences using RNA template of the enzyme. Telomerase activity is highly expressed in immortalized cells but not in most somatic cells, except for some renewal tissues, such as hematopoietic stem cells. Therefore, telomera...

journal_title：Oncology research

authors： Togashi K,Kakeya H,Morishita M,Song YX,Osada H

更新日期：1998-01-01 00:00:00

abstract：:Mutations in the APC gene contribute to development of sporadic desmoid tumors as well as to the hereditary tumors that usually accompany familial adenomatous polyposis (FAP). Adenomatous polyposis coli (APC) mutations cause an intracellular accumulation of beta-catenin that results in abnormal signaling in the wnt/wi...

journal_title：Oncology research

authors： Miyoshi Y,Iwao K,Nawa G,Yoshikawa H,Ochi T,Nakamura Y

更新日期：1998-01-01 00:00:00

abstract：:Whether the phenotypes of drug resistance and metastatic activity in cancer are dependent on each other or not is controversial. We compared in vitro invasive properties of human hepatoma cells resistant to epirubicin and rich in P-glycoprotein (Pgp) (HB8065/R) with the parental epirubicin-sensitive, Pgp-poor cells (H...

journal_title：Oncology research

authors： Bjørnland K,Lehne G,Johansen HT,Fodstad O,Rugstad HE,Aasen AO,Ree AH

更新日期：1998-01-01 00:00:00

abstract：:Concentrations of the flame retardant 2,2',4,4'-tetrabrominated diphenyl ether (2,2',4,4'-TeBDE) in the adipose tissue of 77 individuals from Sweden were determined. The subjects were recruited during the time period 1995-97 and encompassed both men and women ranging from 28 to 85 years in age. Of the subjects include...

journal_title：Oncology research

authors： Hardell L,Lindström G,van Bavel B,Wingfors H,Sundelin E,Liljegren G

更新日期：1998-01-01 00:00:00

abstract：:Synthesis of poly(gamma-glutamyl) metabolites of many antifolates, such as methotrexate (MTX), by folylpolyglutamate synthetase (FPGS) is often essential to their cytotoxic activity. FPGS expression in the MTX-sensitive human T-lymphoblastic leukemia cell line CCRF-CEM and a number of MTX-resistant sublines was previo...

journal_title：Oncology research

authors： McGuire JJ,Russell CA

更新日期：1998-01-01 00:00:00

abstract：:All-trans-Retinoic acid (RA) induces differentiation and inhibits growth of many tumor types. Whereas the RA nuclear receptors mediate genomic effects of RA, there also are many nongenomic effects that do not have defined mechanisms. Some nongenomic effects of RA may involve retinoylation (RA acylation), a posttransla...

journal_title：Oncology research

authors： Takahashi N,Iwahori A,Breitman TR,Fukui T

更新日期：1997-01-01 00:00:00

abstract：:O6-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein that reverses alkylation damage produced by chloroethylnitrosoureas and is a major determinant of cellular resistance to adjuvant chemotherapy with these drugs. AGT activity was measured in 119 samples from 69 patients, including normal, tumor, and dis...

journal_title：Oncology research

authors： White A,Kibitel J,Garcia Y,Belanich M,Yarosh D,Wideroff J,Levin L,Held D,Fuchs A,Citron M

更新日期：1997-01-01 00:00:00

abstract：:HeLa cells were transfected with full-length multidrug resistance protein (MRP) cDNA and with MRP cDNAs that had been mutated at certain nucleotide binding domains. Stable transfectants were isolated and those producing equivalent amounts of P190 were tested in cytotoxicity assays using a variety of chemotherapeutic a...

journal_title：Oncology research

authors： Zhu Q,Sun H,Center MS

更新日期：1997-01-01 00:00:00

abstract：:A1, a member of the Bcl-2 gene family, was originally identified as a hemopoietic-specific early response gene. Later it was found that A1 was overexpressed in human stomach cancer tissues and was induced by tumor necrosis factor-alpha (TNF-alpha) in human vascular endothelial cells. However, its expression in human c...

journal_title：Oncology research

authors： Pang XP,Hershman JM,Karsan A

更新日期：1997-01-01 00:00:00

abstract：:Small-cell lung cancer (SCLC) has a significantly worse prognosis than other forms of bronchogenic carcinoma. Because transforming growth factor beta (TGF-beta) appears to play an important role in the pathogenesis of SCLC, we examined the status of the TGF-beta receptor system in a series of 11 human small-cell carci...

journal_title：Oncology research

authors： de Jonge RR,Garrigue-Antar L,Vellucci VF,Reiss M

更新日期：1997-01-01 00:00:00

abstract：:This commentary proposes the working hypothesis that transforming growth factor-beta (TGF-beta) can play two different and opposite roles with respect to the process of malignant progression. During the earliest stages of carcinogenesis, TGF-beta can act as potent tumor suppressor and may mediate the actions of chemop...

journal_title：Oncology research

authors： Reiss M

更新日期：1997-01-01 00:00:00

abstract：:DNA topoisomerase II alpha is a nuclear enzyme essential for DNA metabolism and cell cycle progression. Previous studies have shown that human tumor cell lines can express more than one topoisomerase II alpha isoform through alternative splicing. A 160-kDa isoform of topoisomerase II alpha has been described in severa...

journal_title：Oncology research

authors： Mo YY,Beck WT

更新日期：1997-01-01 00:00:00

abstract：:DT-diaphorase [also called NAD(P)H:menadione oxidoreductase; NAD(P)H:(quinone acceptor) oxidoreductase; quinone reductase, azo-dye reductase] (EC.1.6.99.2) has been shown to have a role in activation of quinone-containing cancer chemotherapeutic prodrugs to their active form, as well as inactivation of a variety of xe...

journal_title：Oncology research

authors： Rauth AM,Goldberg Z,Misra V

更新日期：1997-01-01 00:00:00

abstract：:The mechanism of action of the anthraquinone antileukemic drug mitoxantrone (MIT) was investigated and compared with that of daunorubicin (DNR) with emphasis on the interaction with DNA to clarify the more potent cytotoxic activity of MIT than DNR in human leukemia cells. MIT showed similar characteristics to those of...

journal_title：Oncology research

authors： Fukushima T,Kawai Y,Nakayama T,Yamauchi T,Yoshida A,Urasaki Y,Imamura S,Kamiya K,Tsutani H,Ueda T,Nakamura T

更新日期：1996-01-01 00:00:00

abstract：:The human nucleolar protein p120 is highly expressed in human cancers. Its high expression in breast cancer correlates with a poor prognosis, and its overexpression in 3T3 mouse fibroblasts causes malignant transformation. This study reports that a combination of monoclonal anti-p 120 antibody (MAbp120), liposomes (Li...

journal_title：Oncology research

authors： Perlaky L,Busch RK,Busch H

更新日期：1996-01-01 00:00:00

abstract：:We have investigated the role of protein kinase C (PKC) in the multidrug resistance (MDR) phenotype of human KB carcinoma cell lines. The PKC activator 12-O-tetradecanoylphorbol-13-acetate (TPA) reduced daunomycin accumulation in both drug-sensitive KB-3-1 and MDR KB-C1 cells in a time-dependent manner. The inactive p...

journal_title：Oncology research

authors： Drew L,Groome N,Warr JR,Rumsby MG

更新日期：1996-01-01 00:00:00

abstract：:N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water. Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (contr...

journal_title：Oncology research

authors： Wada S,Kinoshita Y,Kamizuru M,Asai Y,Iwata H,Ikemoto S,Hato F,Kishimoto T,Fukushima S

更新日期：1996-01-01 00:00:00

abstract：:A majority of tumor cell lines are considered to be "methionine-dependent" because of their inability to grow in culture when methionine is replaced by its precursor, homocysteine. We have previously shown that this phenotype is not due to the incapacity to synthesize methionine from homocysteine but rather to a defic...

journal_title：Oncology research

authors： Dumontet C,Roch AM,Quash G

更新日期：1996-01-01 00:00:00

abstract：:Human colon tumor cell lines that were adapted to grow in chemically defined medium were tested for their growth sensitivity to exogenous transferrin, insulin, and epidermal growth factor (EGF). Less differentiated cell lines, C and HCT116, were able to grow in the presence of a single peptide supplement, to respond s...

journal_title：Oncology research

authors： Yeoman LC,Wan CW,Zorbas MA

更新日期：1996-01-01 00:00:00

abstract：:Topotecan, a topoisomerase I poison and water-soluble derivative of camptothecin, has shown promise in treating solid tumors; however, the drug is unstable under physiological conditions and converts to an inactive form within 30 minutes. Encapsulating topotecan in liposomes (LIP-TPT) minimizes inactivation. The effic...

journal_title：Oncology research

authors： Subramanian D,Muller MT

更新日期：1995-01-01 00:00:00

abstract：:Since recombinant human granulocyte colony-stimulating factor (rhG-CSF) recruits hematopoietic progenitor cells into the cell cycle, the possibility remains that simultaneous injection of rhG-CSF and chemotherapeutic agents may aggravate the chemotherapy-induced neutropenia by sensitizing normal progenitor cells to th...

journal_title：Oncology research

authors： Kabaya K,Obuchi M,Watanabe M,Kusaka M,Seki M

更新日期：1995-01-01 00:00:00

abstract：:Aclacinomycin (ACR) is an anthracycline anticancer drug that shows marked effects in Adriamycin (ADM)-resistant tumors. ADM, however, is not effective against ACR-resistant tumor cells. When tumor cells acquire resistance to ACR, though the resistance is not easily acquired, they show strong cross-resistance to ADM. T...

journal_title：Oncology research

authors： Dong J,Naito M,Tatsuta T,Seimiya H,Johdo O,Tsuruo T

更新日期：1995-01-01 00:00:00

abstract：:Pathophysiological factors exist within solid tumors that lead to a low pH environment. Therefore, pH-sensitive cancer chemotherapeutic agents may selectively target and kill tumor cells while sparing the normal tissue from toxicity. Using colony forming assays to assess cell survival, we found that EMT6 mouse mammary...

journal_title：Oncology research

authors： Laurencot CM,Kennedy KA

更新日期：1995-01-01 00:00:00

abstract：:The patterns of DNA fragmentation were evaluated following a brief exposure (2 h) of the human ileocecal adenocarcinoma cell line, HCT-8, to several specific thymidylate synthase inhibitors, a quinazoline (ZD1694) and benz[cd]indole-containing molecule (AG-331). The magnitude and size of DNA fragmentation induced by t...

journal_title：Oncology research

authors： Panadero A,Yin MB,Voigt W,Rustum YM

更新日期：1995-01-01 00:00:00

abstract：:Adaptive changes occurring in C1300 murine neuroblastoma cell lines developed for resistance to nucleoside analogue inhibitors of S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) were investigated. Two drug-resistant cell lines, rMNB-MDL-7-2 and rMNB-Deaz-7-2, were established from wild-type C1300 neuroblas...

journal_title：Oncology research

authors： Hamre MR,Clark SH,Mirkin BL

更新日期：1995-01-01 00:00:00